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MYP_006586
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Basic Information
pep1c
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
9 amino acids
C46H65N13O19
Standard
Sequence
DKFNHEAED
Physicochemical Analysis
1104.08 Da
4.49
-3.14
-3.40
-0.3492
-2.22
0.48
-0.46
20.86
11.11
0.1111
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
543.11
-5.81
17.0
17.0
37.0
78.0
2.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0053160 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
ACE2-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
PaperNative structure-based peptides as potential protein-protein interaction inhibitors of SARS-CoV-2 spike protein and human ACE2 receptor PMID33918595 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33918595/
RECORD: Rec_0154789 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anti-SARS-CoV Entry inhibition
SARS-CoV spike-pseudotyped virus; HeLa cells
40 %
Pseudovirus infection assay (% inhibition; 100 μM test concentration)
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0171527 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Entry inhibition
SARS-CoV spike-pseudotyped virus; HeLa cells
40 %
Pseudovirus infection assay (% inhibition; 100 μM test concentration)
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0295963 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Entry inhibition
SARS-CoV spike-pseudotyped virus; HeLa cells
40 %
Pseudovirus infection assay (% inhibition; 100 μM test concentration)
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperIdentification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor. | Han DP, Penn-Nicholson A, Cho MW. | Virology. 2006 Jun 20;350(1):15-25. | DOI:10.1016/j.virol.2006.01.029 | PMID:16510163 PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/