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MYP_006585
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Basic Information
Peptide6
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
16 amino acids
C78H124N30O32
Standard
Sequence
SRDKHEEHEKENDRGQ
Physicochemical Analysis
1994.00 Da
5.43
-2.35
-2.67
-0.1471
-3.27
0.32
-0.93
21.75
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1063.23
-14.44
36.0
32.0
73.0
140.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0117237 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Free
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2; HEK293T/ACE2 cells
10±5 nM
IC50 (luciferase virus-entry assay)
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperSynthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein | Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR. | J Med Chem. 2022 Feb 24;65(4):2836-2847. | DOI:10.1021/acs.jmedchem.1c00477 | PMID:34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/
RECORD: Rec_0175423 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Free
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Entry inhibition
SARS-CoV-2; HEK293T/ACE2 cells
10±5 nM
IC50 (luciferase virus-entry assay)
PaperPubMed PMID: 34328726 PMID34328726 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34328726/
RECORD: Rec_0431552 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
ACE2-antagonist peptide
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Free
Amidation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Spike-RBD binding
SARS-CoV-2 spike receptor-binding domain (RBD)
46±5 nM
Kd (microscale thermophoresis)
PaperSynthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein PMID34328726