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MYP_006451
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Basic Information
Glucagon
Hormonal / Endocrine ▸ Hormone peptide
Metabolic
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Antihypoglycemic
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
29 amino acids
C153H225N43O49S
Standard
Sequence
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Physicochemical Analysis
3482.75 Da
6.75
-0.15
-0.41
-0.0053
-0.99
0.66
-0.18
56.03
40.34
0.1724
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1538.74
-17.94
55.0
51.0
113.0
246.0
7.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0137919 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Glucagon
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
XTEN-288
Bio-Activity Profile
Glucose homeostasis
6 hours
ELISA
Monkey plasma (Subcutaneous), in vivo; 32400 s
PMID20418955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20418955/
RECORD: Rec_0175974 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
glucagon family
9823; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-Ser: Phosphoserine
Bio-Activity Profile
Hormone glucagon family
PaperPDB 1GCN structural record; X-ray; 3.00 A; chain A; residues 1-29
RECORD: Rec_0182458 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
glucagon family
9913; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-Ser: Phosphoserine
Bio-Activity Profile
Hormone glucagon family
PaperPDB 1KX6 structural record; NMR; chain A; residues 1-29
RECORD: Rec_0183713 VERIFIED: YES
Provenance & Taxonomy
Canis familiaris [Animal]
Glucagon
9615
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID5102927 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/5102927/
RECORD: Rec_0186415 VERIFIED: YES
Provenance & Taxonomy
Mesocricetus auratus [Animal]
Glucagon
10036
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID2263627 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2263627/
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