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MYP_006451
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Basic Information
Glucagon
Hormonal / Endocrine ▸ Hormone peptide
Metabolic
Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Antihypoglycemic
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Therapeutic / Biomedical activity ▸ Enzyme replacement therapy
Standard
29 amino acids
C153H225N43O49S
Standard
Sequence
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Physicochemical Analysis
3482.75 Da
6.75
-0.15
-0.41
-0.0053
-0.99
0.66
-0.18
56.03
40.34
0.1724
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1538.74
-17.94
55.0
51.0
113.0
246.0
7.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0074419 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Glucagon
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Hormone Hyperglycemic Glucose mobilization Metabolic regulation
beagle dog blood glucose
<2 h
blood glucose pharmacodynamic assay
Not reported, in vivo; <600 s
PMID20418955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20418955/
RECORD: Rec_0084613 VERIFIED: NO
Provenance & Taxonomy
Ovis aries [Animal]
Glucagon
9940
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hormone Metabolic
PMID4421675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4421675/
RECORD: Rec_0093225 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606; 562
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Hormone replacement Enzyme replacement Diagnostic
0.53 hours for subcutaneous auto-injector or pre-filled syringe
RECORD: Rec_0116003 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Cell-Cell Communication
PaperNeuroPedia: neuropeptide database and spectral library PMID21821666 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21821666/
RECORD: Rec_0116389 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Glucagon
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hyperglycemic rescue Hormonal
Clinical/Human: 26 min (IM), 35 min (NP), 32 min (SC)
Evidence URLhttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2002/020918_S003_GLUCAGEN.pdf
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