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MYP_006432
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Basic Information
TC19 (derived from the human thrombocidin-1-derived peptide L3)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C85H133N25O17S3
Standard
Sequence
LRCMCIKWWSGKHPK
Physicochemical Analysis
1873.32 Da
9.85
3.82
3.54
0.2550
-0.59
0.26
-0.12
30.67
52.00
0.1333
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
682.38
-2.92
27.0
25.0
60.0
130.0
6.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0013139 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
e
PMID32376222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376222/
RECORD: Rec_0179774 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
μM TC19 did not permeabilize human fibroblasts
40 μM
Cytotoxicity
PMID32376222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376222/
RECORD: Rec_0209409 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive bacteria: E
PMID32376222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376222/
RECORD: Rec_0214745 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
PMID32376222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376222/
RECORD: Rec_0220227 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Multi-drug resistant (MDR) gram-positive bacteria:E
PMID32376222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32376222/
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