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MYP_006414
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Basic Information
Peptide Ctry2459 (H3)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
9 amino acids
C63H83N15O10
Standard
Sequence
FLHFLHHLF
Physicochemical Analysis
1210.43 Da
7.02
0.02
-0.33
0.0024
1.13
0.54
0.62
-2.63
130.00
0.3333
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
382.16
2.04
13.0
13.0
35.0
88.0
6.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0040364 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human RBC ( HC50 = 416.4 microg/ml ) [HC50
416.4 μg/mL
Hemolysis
PMID23415044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415044/
RECORD: Rec_0053554 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Cytotoxic: Huh7
PaperDesign of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. Biomaterials. 2013 Feb 13;34(13):3511-3522. doi: 10.1016/j.biomaterials.2013.01.075. PMID: 23415044. PMID23415044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415044/
RECORD: Rec_0064884 VERIFIED: YES
Provenance & Taxonomy
Scorpiones [Animal]
Scorpion venom peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal
Hepatitis C virus (Virucidal); Huh7.5.1
0.70222 μM
EC50
PaperDesign of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. | Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z. | Biomaterials. 2013 | PMID:23415044 PMID23415044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415044/
RECORD: Rec_0080291 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HCV Infection inhibition
Hepatitis C virus | 7.5.1 cells
0.7022 μM
EC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperDesign of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. | Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z. | Biomaterials. 2013 Apr;34(13):3511-22. | DOI:10.1016/j.biomaterials.2013.01.075 | PMID:23415044 PMID23415044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415044/
RECORD: Rec_0091251 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Toxicity
Huh7.5.1 cells
>500 μg/mL
LC50
PaperDesign of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus.
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