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MYP_006353
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Basic Information
TP1[I11G]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C95H146N34O20S4
Standard
Sequence
KWCFRVCYRGGCYRRCR
Physicochemical Analysis
2212.65 Da
9.93
5.72
5.45
0.3363
-0.81
0.60
-0.50
25.48
17.06
0.2353
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
920.69
-7.90
41.0
30.0
70.0
153.0
5.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0242116 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii ATCC 700603
0.5 μg/mL
MIC
PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0243446 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
C.neoformanas ATCC 208821
1 μg/mL
MIC
PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0267318 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii clinical isolate 100734512:2
0.5 μg/mL
MIC
PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0272668 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Acinetobacter baumannii BAA
2 μg/mL
MIC
PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
RECORD: Rec_0284978 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus subtilis ATCC 6051(MIC=0.25 Gram-positive bacteria : Bacillus subtilis ATCC 6051(MIC=0.25 μg/ml), Staphylococcus aureus ATCC 43300 (MRSA)(MIC=4 μg/ml);; Gram-negative bacteria : Escherichia coli ATCC 25922(MIC=0.25 μg/ml), Klebsiella pneumoniae ATCC 13883(MIC=0.25 μg/ml), Klebsiella pneumoniae ATCC 700603 (MDR)(MIC=0.5 μg/ml), Klebsiella pneumoniae BAA 2146 (NDM-1 pos)(MIC=2 μg/ml), Klebsiella pneumoniae clinical isolate 100650661 : 1 (XDR;PmxR)(MIC=8 μg/ml), Acinetobacter baumannii ATCC 19606(MIC=0.5 μg/ml), Acinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)(MIC=0.5 μg/ml), Pseudomonas aeruginosa ATCC 27853(MIC=1 μg/ml), Pseudomonas aeruginosa FADDIFA070 (PmxR)(MIC=4 μg/ml);; Fungi : Candida albicans ATCC 90028(MIC=8 μg/ml), Cryptococcus neoformans ATCC 208821
1 μg/mL
MIC
PaperStructure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. PMID: 28960954. PMID28960954 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28960954/
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