Peptide Database

Peptide NameHis-HR1

Function Ontology

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC281H462N80O96

DescriptionStandard

        YENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSV
    

Molecular Weight6497.15 Da

Isoelectric Point (pI)8.38

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0127

GRAVY Index-0.32

Hydrophobic Moment 0.71

Boman Index0.01

Instability Index31.43

Aliphatic Index 94.33

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2948.63

LogP -40.01

H-bond Donors 97.0

H-bond Acceptors 97.0

Rotatable Bonds 226.0

Heavy Atoms 457.0

Ring Count 3.0

Amide Bonds 75.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0249495 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilyHR2-derived fusion inhibitor

Tax ID694009

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetSevere acute respiratory syndrome coronavirus

MethodEC50

RECORD: Rec_0357004 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilyHeptad repeat peptide

Tax ID694009;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsRecombinant construct with C-terminal His6 tag

Bio-Activity Profile

Function

Antiviral Entry inhibitor Fusion inhibitor

TargetSARS coronavirus (Virus entry); Vero E3

MethodEC50

PaperFusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): in search of potent SARS-CoV entry inhibitors. | Chu LH, Chan SH, Tsai SN, Wang Y, Cheng CH, Wong KB, Waye MM, Ngai SM. | J Cell Biochem. 2008 | PMID:18442051 PMID18442051 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18442051/