Peptide Database

Peptide NameLantibiotic nukacin (Nukacin 3299) (Simulancin 3299)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length57 amino acids

Chemical FormulaC275H440N72O91S6

DescriptionStandard

        MENSKVMKDIEVANLLEEVQEDELNEVLGAKKKSGVIPTVSHDCHMNSFQFVFTCCS
    

Molecular Weight6403.25 Da

Isoelectric Point (pI)4.71

Net Charge (pH 7.0)-5.34

Net Charge (pH 7.4) -5.72

Charge Density (pH 7.0) -0.0936

GRAVY Index-0.19

Hydrophobic Moment 0.52

Boman Index0.02

Instability Index30.92

Aliphatic Index 80.18

Aromaticity 0.0526

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2644.74

LogP -27.19

H-bond Donors 90.0

H-bond Acceptors 94.0

Rotatable Bonds 221.0

Heavy Atoms 444.0

Ring Count 6.0

Amide Bonds 62.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0366824 VERIFIED: YES

Provenance & Taxonomy

OrganismStaphylococcus warneri [Bacterium]

FamilyBacteriocin; Lantibiotic

Structure & Mods

Configribosomally encoded bacteriocin peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetLeuconostoc mesenteroides

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