Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length316 amino acids

Chemical FormulaC1603H2548N382O450S17

DescriptionStandard

        FCFTCLPNVSKEHIRFAAVASILEIMFFFLLMQICPLVNKAVEDLNTELKTLNVLAKVDKYAEIEYSMVSSPEVSKSSIDLSLKGEFYNIGKHQEPPFSPTAISLPPQTDKMLYIALSAFTPNSAGFVYNKAGVLSLYITDDMVPKASPFRLNTKTFGVFIPQIAKQFPGLMMKLLLKTEESPKVSFEPKNATLQTSATMTAYAIQPNGTLSPLFVLNVESSVTAHLFLSGMNIAGSLSLNKMKLTLGTSYVGQFQVGTLDTIFQMVLKMVVIPIVNAQLEKGYPLPALKKMQLINPQLQILKDYMLIGTDVQFIS
    

Molecular Weight34916.77 Da

Isoelectric Point (pI)8.58

Net Charge (pH 7.0)3.01

Net Charge (pH 7.4) 2.53

Charge Density (pH 7.0) 0.0095

GRAVY Index0.27

Hydrophobic Moment 0.59

Boman Index0.20

Instability Index45.56

Aliphatic Index 103.04

Aromaticity 0.0949

Extinction Coeff. Reduced 14900.00

Extinction Coeff. Oxidized 15025.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0395527 VERIFIED: NO

Provenance & Taxonomy

OrganismKryptolebias marmoratus [Bacterium]

FamilyBPI

Tax ID37003

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence