Peptide Database

Peptide NameUnnamed

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ CaMKII Inhibitory

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC66H120N22O19

DescriptionStandard

        KKALRRQEVVDAL
    

Molecular Weight1525.79 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.1355

GRAVY Index-0.59

Hydrophobic Moment 0.36

Boman Index-0.39

Instability Index86.18

Aliphatic Index 120.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 706.05

LogP -5.95

H-bond Donors 25.0

H-bond Acceptors 21.0

Rotatable Bonds 55.0

Heavy Atoms 107.0

Ring Count 0.0

Amide Bonds 13.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0366968 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAIP

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

CaMKII Inhibitory

TargetCalmodulin-dependent protein kinase II (CaMKII)

Activity0.94 μM

MethodIC50

PaperIshida A., Shigeri Y., Tatsu Y., Uegaki K., Kameshita I., Okuno S., Kitani T., Yumoto N., Fujisawa H.. Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin-dependent protein kinase II. FEBS Lett., 427, 115-118. PMID9613610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9613610/