Peptide Database

Peptide NameRFamide-related peptide-3

Function Ontology

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC147H237N47O38S

DescriptionStandard

        AMAHLPLRLGKNREDSLSRWVPNLPQRF
    

Molecular Weight3302.81 Da

Isoelectric Point (pI)11.54

Net Charge (pH 7.0)2.89

Net Charge (pH 7.4) 2.64

Charge Density (pH 7.0) 0.1031

GRAVY Index-0.67

Hydrophobic Moment 0.70

Boman Index-0.19

Instability Index80.44

Aliphatic Index 87.14

Aromaticity 0.0714

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1385.07

LogP -12.23

H-bond Donors 48.0

H-bond Acceptors 43.0

Rotatable Bonds 106.0

Heavy Atoms 233.0

Ring Count 7.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0003610 VERIFIED: YES

Provenance & Taxonomy

OrganismPhodopus sungorus [Animal]

FamilyRFamide-related peptide

Tax ID10044

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

-

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0005764 VERIFIED: NO

Provenance & Taxonomy

OrganismIxodes scapularis [Animal]

Tax ID6945

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0032046 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyFMRFamide related peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator

RECORD: Rec_0364418 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/