Peptide Database

Peptide NameSLAY-screened peptide P4971

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC76H123N27O22S2

DescriptionStandard

        NASCPPSCLNHHRGLPK
    

Molecular Weight1831.09 Da

Isoelectric Point (pI)8.96

Net Charge (pH 7.0)1.91

Net Charge (pH 7.4) 1.58

Charge Density (pH 7.0) 0.1126

GRAVY Index-0.84

Hydrophobic Moment 0.42

Boman Index-0.15

Instability Index99.42

Aliphatic Index 51.76

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 774.47

LogP -10.66

H-bond Donors 27.0

H-bond Acceptors 28.0

Rotatable Bonds 54.0

Heavy Atoms 127.0

Ring Count 5.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0088084 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/