Peptide Database

Peptide NameSLAY-screened peptide P4637

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC125H185N35O30S

DescriptionStandard

        LYPRLVRVHQHRCFPYFDLTE
    

Molecular Weight2690.09 Da

Isoelectric Point (pI)8.22

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0444

GRAVY Index-0.43

Hydrophobic Moment 0.56

Boman Index-0.10

Instability Index36.03

Aliphatic Index 83.33

Aromaticity 0.1905

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1049.18

LogP -5.42

H-bond Donors 38.0

H-bond Acceptors 34.0

Rotatable Bonds 81.0

Heavy Atoms 191.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0317336 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/