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MYP_006086
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Basic Information
Peptide 17(lactoferrin 418-421)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
4 amino acids
C18H31N7O7
Standard
Sequence
SKHS
Physicochemical Analysis
457.48 Da
8.49
0.55
0.29
0.1366
-2.17
0.31
-0.56
7.50
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
245.78
-4.07
9.0
9.0
15.0
32.0
1.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002842 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-H1N1 Replication inhibition
A/Roma-ISS/02/08 H1N1 | MDCK cells
0.000003±0.00000061 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperLactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors. | Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P. | Sci Rep. 2017 Sep 6;7(1):10593. | DOI:10.1038/s41598-017-10492-x | PMID:28878220 PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0072503 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ac
Amidation
Bio-Activity Profile
Antiviral
A/Parma/24/09 H1N1
0.048±0.0012
EC50
PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0081254 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ac
Amidation
Bio-Activity Profile
Antiviral
A/Parma/05/06 H3N3
5.0±0.02
EC50
PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0185612 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ac
Amidation
Bio-Activity Profile
Antiviral
A/Roma-ISS/02/08 H1N1
3±0.61
EC50
PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0222010 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Virus:A/Roma-ISS/02/08 H1N1:inhibition of virus replication in MDCK cells
0.000003±0.000001 μM
EC50
PMID28878220;34681184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
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