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MYP_006031
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Basic Information
Seed glutenin fragment 62
Antimicrobial
Antimicrobial ▸ Antibacterial
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
3 amino acids
C13H23N3O4
Standard
Sequence
PLG
Physicochemical Analysis
285.34 Da
5.96
-0.04
-0.10
-0.0138
0.60
0.34
0.55
6.67
130.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
107.53
-0.53
4.0
4.0
7.0
20.0
1.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0094267 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial
recombinant Escherichia coli surface-display screening
SLAY screening
PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/
RECORD: Rec_0179108 VERIFIED: NO
Provenance & Taxonomy
Papio hamadryas [Animal]
Vasopressin/oxytocin
9557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Neurohypophyseal hormone Neuropeptide
RECORD: Rec_0247839 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0267165 VERIFIED: YES
Provenance & Taxonomy
Amaranthus hypochondriacus [Plant]
ACE inhibitory peptide
28502
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide Enzyme inhibitory ACE inhibitory Antihypertensive Opioid
Angiotensin-converting enzyme
PaperBioactive peptides in amaranth (Amaranthus hypochondriacus) seed PMID18211015 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18211015/
RECORD: Rec_0295885 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Tritium labeling at Proline
Bio-Activity Profile
Dopaminergic modulation Anti-parkinsonian
Radioimmunoassay
Subcutaneously injected to rat plasma, in vivo; 1200 s
PMID6121002 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6121002/
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