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MYP_006030
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Basic Information
LL37 (14-21)+Indolicidin (5-13), LI
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C117H167N33O20
Standard
Sequence
GKEFKRIVKWPWWPWRR
Physicochemical Analysis
2355.79 Da
11.73
4.76
4.55
0.2800
-1.44
0.75
-0.31
38.37
40.00
0.2941
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
875.56
-0.32
33.0
25.0
71.0
170.0
11.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0319174 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC25922
4 μM
MIC
PMID29282543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29282543/
RECORD: Rec_0345483 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 29282543 PMID29282543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29282543/
RECORD: Rec_0380628 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes: >128 μM
5 %
Hemolysis
PaperPubMed PMID: 29282543 PMID29282543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29282543/
RECORD: Rec_0392232 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 29213
4 μM
MIC
PMID29282543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29282543/
RECORD: Rec_0422665 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
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