Peptide Database

Peptide NameSLAY-screened peptide P5138

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC95H159N29O29S

DescriptionStandard

        SILAKVYSLLGQHKTCNRDG
    

Molecular Weight2203.52 Da

Isoelectric Point (pI)9.19

Net Charge (pH 7.0)1.54

Net Charge (pH 7.4) 1.26

Charge Density (pH 7.0) 0.0768

GRAVY Index-0.30

Hydrophobic Moment 0.44

Boman Index-0.06

Instability Index22.95

Aliphatic Index 97.50

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 963.24

LogP -10.92

H-bond Donors 35.0

H-bond Acceptors 33.0

Rotatable Bonds 75.0

Heavy Atoms 154.0

Ring Count 2.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0359773 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/