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MYP_005833
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
40 amino acids
C186H285N57O53S6
Standard
Sequence
ATCDLLSKWNWNHTACAGHCIAKGFKGGYCNDKAVCVCRN
Physicochemical Analysis
4359.99 Da
8.65
2.91
2.52
0.0727
-0.18
0.53
0.02
19.28
56.25
0.1000
12490.00
12865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1781.02
-20.49
68.0
64.0
140.0
302.0
8.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0222922 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0232871 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PMID8168509 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8168509/
RECORD: Rec_0244253 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0251327 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Defensin
7227
Structure & Mods
Disulfide-stabilized peptide [Linear]
noncanonical stereochemical modification [Modified]
three disulfide bonds
Bio-Activity Profile
Antimicrobial Anticancer
Drosophila tumour cells
PaperThe antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila PMID31358113 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31358113/
RECORD: Rec_0327935 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Defensin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Micrococcus luteus. It can cause tumor death in drosophila by binding to exposed phosphatidylserine (PS) (Parvy et al., 2019). Updated 4/2017; 7/2019
PaperCharacterization and transcriptional profiles of a Drosophila gene encoding an insect defensin. A study in insect immunity.
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