Peptide Database

Peptide NameLEDGF 365-369

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC35H50N8O12

DescriptionStandard

        WIDNLD
    

Molecular Weight774.82 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.23

Net Charge (pH 7.4) -2.44

Charge Density (pH 7.0) -0.3724

GRAVY Index-0.52

Hydrophobic Moment 0.59

Boman Index0.11

Instability Index8.33

Aliphatic Index 130.00

Aromaticity 0.1667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 342.30

LogP -1.54

H-bond Donors 11.0

H-bond Acceptors 10.0

Rotatable Bonds 23.0

Heavy Atoms 55.0

Ring Count 2.0

Amide Bonds 6.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0174762 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1

RECORD: Rec_0265935 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1[30-40% IN activity = 19.5 microM

RECORD: Rec_0355229 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Integrase inhibition

TargetHIV-1

Activity0.1 μM

Method% inhibition

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperMechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. | Hayouka Z, Levin A, Maes M, Hadas E, Shalev DE, Volsky DJ, Loyter A, Friedler A. | Biochem Biophys Res Commun. 2010 Apr 2;394(2):260-5. | DOI:10.1016/j.bbrc.2010.02.100 | PMID:20171172 PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/