Peptide Database

Peptide NameSpantide II (Neurokinin-1 receptor (NK-1R) antagonist)

Function Ontology

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC55H87N13O13S2

DescriptionStandard

        KNICPPALPFC
    

Molecular Weight1202.49 Da

Isoelectric Point (pI)8.06

Net Charge (pH 7.0)0.74

Net Charge (pH 7.4) 0.51

Charge Density (pH 7.0) 0.0672

GRAVY Index0.52

Hydrophobic Moment 0.35

Boman Index0.26

Instability Index136.58

Aliphatic Index 80.00

Aromaticity 0.0909

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 397.06

LogP -2.02

H-bond Donors 13.0

H-bond Acceptors 16.0

Rotatable Bonds 32.0

Heavy Atoms 83.0

Ring Count 4.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0225830 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNicotinoylation

C-TermAmidation

Other ModsPal=3-(2-Pyridyl)-L-alanine , k(Nic)=Nicotinoyl)Lys , Nle=NorLeucine, Dichloro at 5th Phenyl

Bio-Activity Profile

Function

Anti-inflammatory

MethodHPLC, LC-MS

Half-LifeEthanol -water mixture, in vitro; 8208000 s