Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length441 amino acids

Chemical FormulaC2183H3461N549O636S16

DescriptionStandard

        MSLCCWFILLAFIPEALSTDPGVIVKLTDKGLEYGRQLGMAVIQKQLLTIKVADISGSESVSPIGSVEYRLSNMHIVDVGLPKSEVDLVPGSGVRLFIGNAFISLHGDWKVKYLKIIKDSGSFDLNVNGLTISTSIAIKSDETGRPAVSTVDCVASISSVRVIFHGGASWLYNLFTSFIDRSLRNAIQTQVCPSVANAVSQLNSQLKTLNVVAQVDQYAEIDYSMVSSPMVSQSSIDLSLKGEFYNVGKHQEPPFSPTPFSLSSQLSNMLYFGMSAFTANSAAFVYNSAGALSLYITDDMIPHTSLFRLNTMTFGAFIPQVAKLFPGLLMKLLVQTVKTPVITFEPNNATIQATGTVTAYAILPNTTLSPLFVLNLETSVSTKVFVREMRLAGAVTLNKMDLTLRTSYVREFQVKSLDNFLQVVLKGVVIPKVNGEFLYFT
    

Molecular Weight48086.17 Da

Isoelectric Point (pI)7.63

Net Charge (pH 7.0)0.92

Net Charge (pH 7.4) 0.31

Charge Density (pH 7.0) 0.0021

GRAVY Index0.32

Hydrophobic Moment 0.79

Boman Index0.19

Instability Index28.64

Aliphatic Index 104.92

Aromaticity 0.0930

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0036741 VERIFIED: NO

Provenance & Taxonomy

OrganismMonopterus albus [Animal]

FamilyBPI

Tax ID43700

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence