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MYP_005724
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
47 amino acids
C223H374N68O65S8
Standard
Sequence
RECKTESNTFPGICITKPPCRKACISEKFTDGHCSKILRRCLCTKPC
Physicochemical Analysis
5304.29 Da
9.08
5.77
5.39
0.1228
-0.47
0.63
-0.21
71.18
51.91
0.0426
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2153.29
-25.17
84.0
80.0
176.0
364.0
7.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0320428 VERIFIED: YES
Provenance & Taxonomy
Nicotiana alata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial Antifungal Insecticidal
Puccinia sorghi
2 μM
IC50
PaperPubMed PMID 12644678 | PubMed PMID 23689710 PMID12644678;23689710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12644678/
RECORD: Rec_0322479 VERIFIED: YES
Provenance & Taxonomy
Nicotiana alata [Plant]
DEFL family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-47; 14-34; 20-41; 24-43
Bio-Activity Profile
Antimicrobial DEFL family Antifungal Host defense
PaperPDB 4AB0 structural record; X-ray; 1.64 A; chain A/B; residues 1-47
RECORD: Rec_0330784 VERIFIED: YES
Provenance & Taxonomy
Nicotiana alata [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Insecticidal
T. bisicola
0.8 μM
IC50
PaperThe three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP.
RECORD: Rec_0334617 VERIFIED: YES
Provenance & Taxonomy
Nicotiana alata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial Antifungal Insecticidal
Aspergillus niger
2.1±0.76 μM
IC50
PaperPubMed PMID 12644678 | PubMed PMID 23689710 PMID12644678;23689710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12644678/
RECORD: Rec_0337794 VERIFIED: YES
Provenance & Taxonomy
Nicotiana alata [Plant]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
HeLa cells
10 μM
IC50
PaperPubMed PMID: 12644678 | PubMed PMID: 12473460 | PubMed PMID: 22511788 | PubMed PMID: 18339623 PMID12644678;12473460;22511788;18339623 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12644678/
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