Peptide Database

Peptide NamePancrelipase lipase

Function Ontology

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length450 amino acids

Chemical FormulaC2227H3404N610O674S18

DescriptionStandard

        SEVCFPRLGCFSDDAPWAGIVQRPLKILPWSPKDVDTRFLLYTNQNQNNYQELVADPSTITNSNFRMDRKTRFIIHGFIDKGEEDWLSNICKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQKNILSQIVDIDGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPCPSEGCPQMGHYADRFPGKTNGVSQVFYLNTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVKFIWYNNNVINPTLPRVGASKITVERNDGKVYDFCSQETVREEVLLTLNPC
    

Molecular Weight50083.70 Da

Isoelectric Point (pI)5.73

Net Charge (pH 7.0)-7.75

Net Charge (pH 7.4) -8.78

Charge Density (pH 7.0) -0.0172

GRAVY Index-0.36

Hydrophobic Moment 0.69

Boman Index0.02

Instability Index32.65

Aliphatic Index 74.89

Aromaticity 0.1067

Extinction Coeff. Reduced 62340.00

Extinction Coeff. Oxidized 63215.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0361625 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyEnzyme

Tax ID9823

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideDisulfide-bonded therapeutic scaffold described in source text

Other ModsLipidation

Bio-Activity Profile

Function

Enzyme replacement

TargetCHO

Half-LifePancrelipase acts locally in the GI tract and it is not absorbed in any significant amount thus, the elimination half-life is not relevant.105