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MYP_005706
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Basic Information
Prokineticin Bv8
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
77 amino acids
C335H539N101O108S10
Standard
Sequence
AVITGACDKDVQCGSGTCCAASAWSRNIRFCIPLGNSGEDCHPASHKVPYDGKRLSSLCPCKSGLTCSKSGEKFKCS
Physicochemical Analysis
8030.13 Da
8.59
3.87
3.42
0.0503
-0.24
0.59
-0.03
40.68
54.55
0.0519
6990.00
7615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3337.27
-46.49
127.0
124.0
263.0
554.0
11.0
79.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0026125 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Prokineticin Bv8
8348
Structure & Mods
linear peptide with reported disulfide constraint [Linear]
canonical L-amino-acid peptide [L]
7-19; 13-31; 18-59; 41-67; 61-76
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory
guinea-pig gastrointestinal (GI) smooth muscle
Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PMID10422759;20677202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10422759/
RECORD: Rec_0225361 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Prokineticin Bv8
8348
Structure & Mods
linear peptide with reported disulfide constraint [Linear]
canonical L-amino-acid peptide [L]
7-19; 13-31; 18-59; 41-67; 61-76
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory
neuroblastoma cells (SH-SY5Y) which endogenously express mainly PKR2/PROKR2 (PubMed:20677202)
0.000264 μM
EC50
Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PMID20677202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20677202/
RECORD: Rec_0316965 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Prokineticin Bv8
8348
Structure & Mods
linear peptide with reported disulfide constraint [Linear]
canonical L-amino-acid peptide [L]
7-19; 13-31; 18-59; 41-67; 61-76
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory
Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PMID10422759;12466223;20677202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10422759/
RECORD: Rec_0360807 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
AVIT (prokineticin) family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
7-19; 13-31; 18-59; 41-67; 61-76
Bio-Activity Profile
Toxin Venom AVIT (prokineticin) family
PaperPDB 2KRA structural record; NMR; chain A; residues 1-77
RECORD: Rec_0380845 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Prokineticin Bv8
8348
Structure & Mods
linear peptide with reported disulfide constraint [Linear]
canonical L-amino-acid peptide [L]
7-19; 13-31; 18-59; 41-67; 61-76
Bio-Activity Profile
Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory
DRG neurons (PubMed:16687502, PubMed:20677202)
Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PMID16687502;20677202 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16687502/