‹ ›
MYP_005689
← PREVIOUS NEXT → BACK
Basic Information
Brevinin-1BYb (Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C123H208N28O27S2
Standard
Sequence
FLPILASLAAKLGPKLFCLVTKKC
Physicochemical Analysis
2575.27 Da
9.70
3.74
3.50
0.1557
1.12
0.49
0.34
23.05
138.33
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
859.58
-2.54
31.0
33.0
84.0
180.0
4.0
23.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0192340 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anti-Gram-positive
Staphylococcus aureus
4 μM
MIC
RECORD: Rec_0207719 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic
Candida albicans
16 μM
MIC
RECORD: Rec_0271972 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human erythrocytes
4 μM
HC50
PaperPubMed PMID: 14531844 PMID14531844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14531844/
RECORD: Rec_0287279 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PMID14531844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14531844/
RECORD: Rec_0312262 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
4.0 μM
HC50
PaperJ.M. Conlon et al. / J. Peptide Res. 62 (2003) 207-213. Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii Evidence URLhttps://www.uniprot.org/uniprotkb/P84112/entry
FIRST PREV 1 2 3 4 5 6 NEXT LAST
Showing 5 records on this page · Page 4 of 6