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MYP_005689
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Basic Information
Brevinin-1BYb (Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C123H208N28O27S2
Standard
Sequence
FLPILASLAAKLGPKLFCLVTKKC
Physicochemical Analysis
2575.27 Da
9.70
3.74
3.50
0.1557
1.12
0.49
0.34
23.05
138.33
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
859.58
-2.54
31.0
33.0
84.0
180.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0138324 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anti-Gram-negative
Escherichia coli
16 μM
MIC
RECORD: Rec_0170368 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
16 μM
MIC
PaperPubMed PMID: 14531844 PMID14531844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14531844/
RECORD: Rec_0172528 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
Human erythrocytes
4 μM
HC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/14531844/ PMID14531844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14531844/
RECORD: Rec_0175288 VERIFIED: YES
Provenance & Taxonomy
Rana boylii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-positive Cytolytic Hemolytic
Staphylococcus aureus
PMID14531844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14531844/
RECORD: Rec_0178111 VERIFIED: NO
Provenance & Taxonomy
American frog [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
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