Peptide Database

Peptide NameSLAY-screened peptide P1396

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H179N45O23S3

DescriptionStandard

        RSCAGAMRRSIGRWMRLRRR
    

Molecular Weight2475.97 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.75

Net Charge (pH 7.4) 7.53

Charge Density (pH 7.0) 0.3875

GRAVY Index-1.05

Hydrophobic Moment 0.82

Boman Index-0.68

Instability Index193.99

Aliphatic Index 49.00

Aromaticity 0.0500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1167.67

LogP -13.74

H-bond Donors 49.0

H-bond Acceptors 34.0

Rotatable Bonds 86.0

Heavy Atoms 171.0

Ring Count 2.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0360492 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/