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MYP_005615
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Basic Information
PN-CATH2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C139H253N41O36S2
Standard
Sequence
EGCNILCLLKRKVKAVKNVVKNVVKSVVG
Physicochemical Analysis
3138.88 Da
10.05
5.81
5.60
0.2004
0.44
0.74
0.02
36.58
137.24
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1282.94
-10.93
46.0
44.0
113.0
218.0
0.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0311838 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Vibrio harveyi
75 μg/mL
MIC
PMID33242568 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33242568/
RECORD: Rec_0316131 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculata [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-7
Bio-Activity Profile
Antimicrobial Antioxidant Anti-inflammatory
inactive: Bacillus cereus CMCC63301, Enterococcus faecalis ATCC 29212, Staphylococcus epidermidis, E.faecium
>100 μM
MIC
PaperIdentification and characterization of novel bi-functional cathelicidins from the black-spotted frog (Pelophylax nigromaculata) with both anti-infective and antioxidant activities.
RECORD: Rec_0317746 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Aeromonas hydrophila
37.5 μg/mL
MIC
PMID33242568 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33242568/
RECORD: Rec_0330461 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Bacillus subtilis CMCC 63501
37.5 μg/mL
MIC
PMID33242568 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33242568/
RECORD: Rec_0334627 VERIFIED: YES
Provenance & Taxonomy
Pelophylax nigromaculata [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-7
Bio-Activity Profile
Antimicrobial Antioxidant Anti-inflammatory
Candida albicans and C.glabrata
>100 μM
MIC
PaperIdentification and characterization of novel bi-functional cathelicidins from the black-spotted frog (Pelophylax nigromaculata) with both anti-infective and antioxidant activities.
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