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MYP_005577
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Basic Information
Protegrin-5 (Protegrin 5; PG-5; pigs, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C87H145N33O20S4
Standard
Sequence
RGGRLCYCRPRFCVCVGR
Physicochemical Analysis
2101.55 Da
9.88
4.72
4.46
0.2622
-0.09
0.50
-0.29
5.00
53.89
0.1111
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
878.96
-9.38
38.0
29.0
66.0
144.0
3.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015765 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PaperPubMed PMID: 7628604 PMID7628604 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628604/
RECORD: Rec_0043923 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US20110302675A1/en PatentUS 2011/0302675 A1
RECORD: Rec_0138021 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
80 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/18455267/ PMID18455267 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18455267/
RECORD: Rec_0171979 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
cathelicidin family
9823; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
6-15; 8-13
Bio-Activity Profile
Antimicrobial cathelicidin family Antibacterial Host defense
PaperPDB 2NC7 structural record; NMR; chain A; residues 1-18
RECORD: Rec_0217675 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Cathelicidin
9823
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
P49934
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Candida albicans (Cho Y et al., 1998). Chemical modification: Two disulfide bridges:6,15; 8,13; Structure: You can rotate, zoom
PaperThe structure of porcine protegrin genes.
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