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MYP_005552
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Basic Information
Temporin-PE
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C69H118N14O15
Standard
Sequence
FLPIVAKLLSGLL
Physicochemical Analysis
1383.76 Da
8.75
0.76
0.55
0.0584
1.97
0.44
0.65
10.98
210.00
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
449.98
0.67
15.0
16.0
44.0
98.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0147621 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl. esculentus [Animal]
Temporins
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
MDA-MB-435S (skin cancer)
33.23 μM
IC50
PaperIdentification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. esculentus | https://pubmed.ncbi.nlm.nih.gov/29191658/ PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
RECORD: Rec_0152865 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl. esculentus [Animal]
Temporins
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
PC-3 (prostate cancer)
38.56 μM
IC50
PaperIdentification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. esculentus | https://pubmed.ncbi.nlm.nih.gov/29191658/ PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
RECORD: Rec_0153219 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl.esculentus [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
4.0 μM
MIC
PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
RECORD: Rec_0184234 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl.esculentus [Animal]
Temporin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Anticancer Anti-Gram-negative Hemolytic
horse red blood cells
PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
RECORD: Rec_0216651 VERIFIED: YES
Provenance & Taxonomy
Pelophylax kl.esculentus [Animal]
Temporin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Anticancer Anti-Gram-negative
Enterococcus faecalis
8 μM
MIC
PMID29191658 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29191658/
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