Peptide Database

Peptide NameDermaseptin AA-3-4

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length72 amino acids

Chemical FormulaC358H574N94O117S3

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSICDEEKRENEDEEEQEDDEQSEEKRGMWGSLLKGVATVVKHVLPHALSSQQS
    

Molecular Weight8163.14 Da

Isoelectric Point (pI)4.65

Net Charge (pH 7.0)-7.31

Net Charge (pH 7.4) -7.67

Charge Density (pH 7.0) -0.1015

GRAVY Index-0.39

Hydrophobic Moment 0.60

Boman Index-0.04

Instability Index73.82

Aliphatic Index 93.33

Aromaticity 0.0556

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3430.72

LogP -31.81

H-bond Donors 117.0

H-bond Acceptors 115.0

Rotatable Bonds 287.0

Heavy Atoms 572.0

Ring Count 8.0

Amide Bonds 76.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0022900 VERIFIED: NO

Provenance & Taxonomy

OrganismAgalychnis annae [Animal]

FamilyFrog skin active peptide (FSAP)

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetGram-negative bacteria; Gram-positive bacteria

MethodQualitative functional evidence