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MYP_005481
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Basic Information
CNBr-cleaved lactoferricin Subfragment 1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Standard
9 amino acids
C63H92N22O11S
Standard
Sequence
FKCRRWQWR
Physicochemical Analysis
1365.61 Da
11.71
3.75
3.53
0.4166
-1.93
0.35
-0.76
119.48
0.00
0.3333
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
582.51
-2.92
24.0
16.0
43.0
97.0
5.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0175248 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Linked with a homoserine lactone
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus cereus
20 μM
MIC
PaperPubMed PMID: 8980754 PMID8980754 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8980754/
RECORD: Rec_0183949 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Linked with a homoserine lactone
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli O:9
15 μM
MIC
PaperPubMed PMID: 8980754 PMID8980754 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8980754/
RECORD: Rec_0239553 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli; Bacillus cereus; Listeria monocytogenes; Pseudomonas fluorescens
MIC
PaperAntibacterial activity in bovine lactoferrin-derived peptides | Hoek, KS. et al. | DOI: 10.1128/aac.41.1.54 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
RECORD: Rec_0249857 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Linked with a homoserine lactone
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
50 μM
MIC
PaperPubMed PMID: 8980754 PMID8980754 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8980754/
RECORD: Rec_0305108 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
IC50
PaperAntihypertensive Properties of Lactoferricin β-Derived Peptides | Ruiz-Gimenez, P. et al. | DOI: 10.1021/jf100899u Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry
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