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MYP_005481
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Basic Information
CNBr-cleaved lactoferricin Subfragment 1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Standard
9 amino acids
C63H92N22O11S
Standard
Sequence
FKCRRWQWR
Physicochemical Analysis
1365.61 Da
11.71
3.75
3.53
0.4166
-1.93
0.35
-0.76
119.48
0.00
0.3333
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
582.51
-2.92
24.0
16.0
43.0
97.0
5.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037428 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Linked with a homoserine lactone
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli L361
10 μM
MIC
PaperPubMed PMID: 8980754 PMID8980754 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8980754/
RECORD: Rec_0040094 VERIFIED: YES
Provenance & Taxonomy
Escherichia coli [Bacterium]
562.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperHuertas N. J., Rivera Monroy Z. J., Fierro Medina R., Garc¨ªa Casta?eda J. E.. Antimicrobial activity of truncated and polyvalent peptides derived from the FKCRRWQWRMKKGLA sequence against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923. Molecules, 22, Article No 987, 2017.
RECORD: Rec_0068986 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Transferrin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922(MIC=100microM),(MBC=100microM); S. aureusATCC 25923(MIC=>200microM),(MBC=>200microM)
200 μM
MBC
PMID28613262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28613262/
RECORD: Rec_0093421 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Transferrin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S. aureusATCC 25923
200 μM
MIC
PMID28613262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28613262/
RECORD: Rec_0149577 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Transferrin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922(MIC=100microM),(MBC=100microM); S. aureusATCC 25923(MIC=>200microM),(MBC=>200microM)
100 μM
MBC
PMID28613262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28613262/
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