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MYP_005429
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Basic Information
Unnamed
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C127H203N31O42S6
Standard
Sequence
TPCGESCVYIPCISGVIGCSCTDKVCYLN
Physicochemical Analysis
3028.54 Da
4.37
-1.66
-1.94
-0.0573
0.68
0.29
0.27
30.17
83.79
0.0690
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1145.86
-13.41
45.0
47.0
92.0
206.0
4.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000859 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Toxic Cytotoxic
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0027623 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Defensin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20; 8-22; 13-27
Hydrogen bonds between the side chain carboxyl group of Glu6 and the backbone amide protons of Ile14 and Ser15, as well as the side chain hydroxyl proton of Ser15
Bio-Activity Profile
Not found Hemolytic
PaperPubMed PMID: 10600388 | PubMed PMID: 17534989 | PubMed PMID: 20564013 PMID10600388;17534989;20564013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0038292 VERIFIED: YES
Provenance & Taxonomy
Viola betonicifolia [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antiparasitic
PaperPlant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0154081 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0191755 VERIFIED: YES
Provenance & Taxonomy
Arrowhead violet [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
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