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MYP_005314
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Basic Information
Esculentin 2 HYba2 (E2/2)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C168H286N46O48S3
Standard
Sequence
SILSLFKMGAKALGKTLIKQAGKAGAEYVACKATNQC
Physicochemical Analysis
3814.54 Da
9.70
4.44
4.19
0.1199
0.20
0.60
0.12
18.34
90.00
0.0541
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1534.76
-15.96
55.0
56.0
134.0
265.0
2.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0235289 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus gordonnii MTCC 2695
5 μM
MIC
PMID31328553 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31328553/
RECORD: Rec_0237137 VERIFIED: YES
Provenance & Taxonomy
H. bahuvistara [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
VRE ATCC 29212
18 μM
MIC
PMID31328553 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31328553/
RECORD: Rec_0279809 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hydrophylax bahuvistara [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
31-37
Bio-Activity Profile
Antimicrobial Anticancer
S. mutans MTCC 497
5 μM
MIC
PaperIdentification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog.
RECORD: Rec_0291226 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Vibrio cholerae MCV09
7 μM
MIC
PMID31328553 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31328553/
RECORD: Rec_0304445 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hydrophylax bahuvistara [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
31-37
Bio-Activity Profile
Antimicrobial Anticancer
fish pathogens A. hydrophilia
20 μM
MIC
PaperIdentification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog.
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