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MYP_005314
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Basic Information
Esculentin 2 HYba2 (E2/2)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C168H286N46O48S3
Standard
Sequence
SILSLFKMGAKALGKTLIKQAGKAGAEYVACKATNQC
Physicochemical Analysis
3814.54 Da
9.70
4.44
4.19
0.1199
0.20
0.60
0.12
18.34
90.00
0.0541
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1534.76
-15.96
55.0
56.0
134.0
265.0
2.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0202321 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus mutans MTCC 497
5 μM
MIC
PMID31328553 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31328553/
RECORD: Rec_0208330 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
MRSA ATCC 43300
3 μM
MIC
PMID31328553 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31328553/
RECORD: Rec_0217523 VERIFIED: YES
Provenance & Taxonomy
H. bahuvistara [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Aeromonas hydrophilia
100 μM
MIC
PMID31328553 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31328553/
RECORD: Rec_0217931 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hydrophylax bahuvistara [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
31-37
Bio-Activity Profile
Antimicrobial Anticancer
Aeromonas sobria
3 μM
MIC
PaperIdentification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog.
RECORD: Rec_0228184 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hydrophylax bahuvistara [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
31-37
Bio-Activity Profile
Antimicrobial Anticancer
Staphylococcus aureus MTCC 9542 or MRSA ATCC 43300
1.5-3 μM
MIC
PaperIdentification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog.
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