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MYP_005314
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Basic Information
Esculentin 2 HYba2 (E2/2)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C168H286N46O48S3
Standard
Sequence
SILSLFKMGAKALGKTLIKQAGKAGAEYVACKATNQC
Physicochemical Analysis
3814.54 Da
9.70
4.44
4.19
0.1199
0.20
0.60
0.12
18.34
90.00
0.0541
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1534.76
-15.96
55.0
56.0
134.0
265.0
2.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003341 VERIFIED: YES
Provenance & Taxonomy
H. bahuvistara [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human RBCs
10 μM
HC50
PMID31328553 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31328553/
RECORD: Rec_0004824 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hydrophylax bahuvistara [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
31-37
Bio-Activity Profile
Antimicrobial Anticancer
S. gordonnii MTCC 2695
5 μM
MIC
PaperIdentification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog.
RECORD: Rec_0005504 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
human RBCs
12 μM
HC50
PMID31328553 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31328553/
RECORD: Rec_0011082 VERIFIED: YES
Provenance & Taxonomy
H. bahuvistara [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli. ATCC 25922
15 μM
MIC
PMID31328553 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31328553/
RECORD: Rec_0011242 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Hydrophylax bahuvistara [Synthetic]
Esculentin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
31-37
Bio-Activity Profile
Antimicrobial Anticancer
VRE ATCC 29212
12 μM
MIC
PaperIdentification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog.
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