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MYP_005286
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Basic Information
Dermaseptin K4S4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C133H232N36O32
Standard
Sequence
ALWKTLLKKVLKAAAKAALNAVLVGANA
Physicochemical Analysis
2847.49 Da
10.60
4.79
4.60
0.1711
0.82
0.71
0.26
2.94
146.79
0.0357
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1101.32
-6.96
38.0
37.0
97.0
201.0
2.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0040118 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HSV-2 acyclovir-sensitive strain(911411):inhibition the cytopathic effect(CPE) of HSV-2 in Vero cells
2.7 μM
EC50
PMID23161023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23161023/
RECORD: Rec_0059627 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Vero cells
12 μM
CC50
PMID23161023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23161023/
RECORD: Rec_0082486 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-2 acyclovir-resistant strain (ROI2) | Vero cells
5.1 μM
EC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperIn vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2. | Bergaoui I, Zairi A, Tangy F, Aouni M, Selmi B, Hani K. | J Med Virol. 2013 Feb;85(2):272-81. | DOI:10.1002/jmv.23450 | PMID:23161023 PMID23161023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23161023/
RECORD: Rec_0142137 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human RBCs
0.5±0.1 μM
LC50
PMID10660589 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10660589/
RECORD: Rec_0148182 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
PMID10660589 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10660589/
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