Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length579 amino acids

Chemical FormulaC2830H4476N796O812S19

DescriptionStandard

        MKVAAVAPSPLPAGAGGPLKAVRPGEAARCGPGPGVSPVAAEQAAAALLYDMKGCYSRLRALVPTLPRHRKVSKVELLQHVIDYIWDLQLELQCGPPRPAAAADSPEPRHQSWHQGLADPEDTGVWYPSPFLGITPNSHFAPGRRFGLELLQSTLQKEHEMNLTGSYNTPLLGTLTYAVPRIHIHELQMNESTLDFAEGVGVRLMVQRARIQLSADWAAQLGAVQDSGSVELRMQDLAMAAVLGVSEDGSGRPTVWSAGCDTHGTDLHMEFHRGYSWLYNLLAPLLQRTLRQQLNKQLCLVLNRGVDRLDAVLKHMKVSTQLDNFAAIDHSLLGPPAFTEESGDIALKVTSSQVSLGQIWEWRSLADPHIRVSVQGEIFRVGTYQQRPSALPVALPVALPMALPVALPTPLPRTPPMAHEPTLLLAVTEFLANSAAFTYFTAGALRRNFSSNTLPRQFPLQLRTKSMEVFSPELQERYPDRPMELHLWARQQPLLSCQPDALHGSLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLRVTQVASNVGPVEGFVLIATDLQYEP
    

Molecular Weight63251.89 Da

Isoelectric Point (pI)7.00

Net Charge (pH 7.0)0.00

Net Charge (pH 7.4) -1.26

Charge Density (pH 7.0) 0.0000

GRAVY Index-0.09

Hydrophobic Moment 0.70

Boman Index0.07

Instability Index46.81

Aliphatic Index 93.87

Aromaticity 0.0674

Extinction Coeff. Reduced 67380.00

Extinction Coeff. Oxidized 67755.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0285924 VERIFIED: NO

Provenance & Taxonomy

OrganismHirundo rustica rustica [Bacterium]

FamilyBPI

Tax ID333673

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence