Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length264 amino acids

Chemical FormulaC1344H2093N339O393S5

DescriptionStandard

        MEKPILKNLNEMLCPIITGEVEALNANLSALEVLTKIDNYTLLDYSLIDSPEVTENYLDLNLKGVFYPLDNLADPPFSPVPFVLPERSDSMLYIGISEYFFKSASFAYFTAGAFDVTLSTKEISNHFVQNSQGLGNVLSRVASTSVGLVILGQRLICSLSLNRFRLSLPEPNHSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFVNSDIEVLEGFLLISTDLKYETSSKRQPSFHGWEGLNLISRQWRGEPAP
    

Molecular Weight29448.36 Da

Isoelectric Point (pI)5.05

Net Charge (pH 7.0)-9.04

Net Charge (pH 7.4) -9.60

Charge Density (pH 7.0) -0.0342

GRAVY Index0.05

Hydrophobic Moment 0.72

Boman Index0.14

Instability Index46.66

Aliphatic Index 106.33

Aromaticity 0.0985

Extinction Coeff. Reduced 22920.00

Extinction Coeff. Oxidized 23045.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0373696 VERIFIED: NO

Provenance & Taxonomy

OrganismPropithecus coquereli [Bacterium]

FamilyBPI

Tax ID379532

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence