Peptide Database

Peptide NameSLAY-screened peptide P2463

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC117H166N32O29

DescriptionStandard

        TPHYFRNQPLFHQTHITYLA
    

Molecular Weight2484.77 Da

Isoelectric Point (pI)8.34

Net Charge (pH 7.0)0.66

Net Charge (pH 7.4) 0.31

Charge Density (pH 7.0) 0.0329

GRAVY Index-0.65

Hydrophobic Moment 0.26

Boman Index0.04

Instability Index65.47

Aliphatic Index 63.50

Aromaticity 0.2000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 977.00

LogP -7.13

H-bond Donors 33.0

H-bond Acceptors 33.0

Rotatable Bonds 72.0

Heavy Atoms 178.0

Ring Count 9.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0424359 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/