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MYP_005130
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Basic Information
DC1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C144H228N38O46S6
Standard
Sequence
GAFLKCGESCVYLPCLTTVVGCSCQNSVCYRD
Physicochemical Analysis
3419.97 Da
6.15
-0.30
-0.59
-0.0092
0.51
0.38
0.16
23.09
75.94
0.0938
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1346.94
-16.06
53.0
52.0
107.0
234.0
4.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0094347 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
LNCaP
5.03 μM
IC50
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
RECORD: Rec_0107365 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PC-3
2.24 μM
IC50
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
RECORD: Rec_0112895 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Cycloviolin C. Mol. Wt: 3414.0; GRAVY=0.506. Kill human prostate cancer cells: LNcap
5.03 μM
IC50
PaperNovel cyclotides from Hedyotis diffusa induce apoptosis and inhibit proliferation and migration of prostate cancer cells
RECORD: Rec_0219404 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Plant]
Cyclotide
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
prostate cancer cells
2.24 μM
IC50
RECORD: Rec_0221350 VERIFIED: YES
Provenance & Taxonomy
Hedyotis diffusa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 26064310 PMID26064310 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26064310/
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