Peptide Database

Peptide NameSLAY-screened peptide P498

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC122H186N26O31

DescriptionStandard

        FSLYIRTYTNYKTNIILYII
    

Molecular Weight2512.94 Da

Isoelectric Point (pI)9.40

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.54

Charge Density (pH 7.0) 0.0878

GRAVY Index0.47

Hydrophobic Moment 0.44

Boman Index0.27

Instability Index21.82

Aliphatic Index 136.50

Aromaticity 0.2500

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 952.16

LogP -3.75

H-bond Donors 35.0

H-bond Acceptors 33.0

Rotatable Bonds 79.0

Heavy Atoms 179.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0354171 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/