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MYP_004938
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Basic Information
alpha',beta'-epoxyketone epoxomicin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Proteasome inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
not Standard
3 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0054262 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
-NH2
Ornithine at 1,2; unspecified non-canonical residue at 3; Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
PMID22986997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22986997/
RECORD: Rec_0058638 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)12CO
Amidation
Ornithine at 1,2,3; Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Cryptococcus neoformans ATCC 2344
12.5 μg/mL
PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
RECORD: Rec_0062091 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cyclic peptide
32630
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
None
R=CH3
Bio-Activity Profile
Antimicrobial Antibiotic Antiparasitic Antimalarial
Plasmodium falciparum K1
EC50; PLDH assay
PMID19299148 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19299148/
RECORD: Rec_0070995 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cyclic peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum W2 Indochina
4.3 μM
IC50; Fluorimetry (PicoGreen)
PMID17441769 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17441769/
RECORD: Rec_0073040 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)14CO
Amidation
Ornithine at 1,2,3; Ornithine
Bio-Activity Profile
Hemolytic
human red blood cells
750 μg/mL
Hemolysis
PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
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