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MYP_004938
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Basic Information
alpha',beta'-epoxyketone epoxomicin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Proteasome inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
not Standard
3 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0034646 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
-NH2
Ornithine at 1,2; unspecified non-canonical residue at 3; Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
>227.2
MIC
PMID22986997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22986997/
RECORD: Rec_0036138 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
CH3(CH2)6CO
Amidation
Ornithine at 1,2,3; Ornithine
Bio-Activity Profile
Hemolytic
human red blood cells
1000 μg/mL
Hemolysis
PMID23819506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23819506/
RECORD: Rec_0039091 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oligo-acyl-lysyl
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
L=lauric acid
Bio-Activity Profile
Antimicrobial Antimalarial Antiparasitic
Plasmodium falciparum W2
0.85 μM
IC50; [3H] Hypoxanthine incorporation assay
PMID17307975 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17307975/
RECORD: Rec_0042499 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
residue-level stereochemical modification [Mixed]
None
None
L=lauric acid
Bio-Activity Profile
Antiparasitic Antimicrobial Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0046367 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
ornithine at 1,2; unspecified non-canonical residue at 3
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
14.2
MIC
PMID22986997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22986997/
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