Peptide Database

Peptide Namefragment of beta-amyloid protein: 1-28

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC145H209N41O46

DescriptionStandard

        DAEFRHDSGYEVHHQKLVFFAEDVGSNK
    

Molecular Weight3262.46 Da

Isoelectric Point (pI)5.31

Net Charge (pH 7.0)-2.97

Net Charge (pH 7.4) -3.34

Charge Density (pH 7.0) -0.1061

GRAVY Index-0.90

Hydrophobic Moment 0.39

Boman Index-0.12

Instability Index26.95

Aliphatic Index 52.14

Aromaticity 0.1429

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1419.67

LogP -13.96

H-bond Donors 48.0

H-bond Acceptors 46.0

Rotatable Bonds 108.0

Heavy Atoms 232.0

Ring Count 7.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0213393 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

PaperCasta?o J. M., Ghiso J., Prelli F., Gorevic P. D., Migheli A., Frangione B.. In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein. Biochem. Biophys. Res. Commun., 141, 782-789, 1986. Evidence URLhttps://pubchem.ncbi.nlm.nih.gov/compound/16135494