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MYP_004817
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Basic Information
Esculentin-2P (Frogs, amphibians, animals)
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Standard
37 amino acids
C176H296N50O45S2
Standard
Sequence
GFLSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC
Physicochemical Analysis
3896.67 Da
10.21
5.74
5.50
0.1550
0.48
0.75
0.13
16.78
108.11
0.0811
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1548.99
-14.27
57.0
53.0
136.0
273.0
3.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010511 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Ranatuerin
8404
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
31-37
Bio-Activity Profile
Antiviral Anti-FV3 Entry inhibition
frog virus 3
500 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. | Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. | Virology. 2001 Sep 30;288(2):351-7. | DOI:10.1006/viro.2001.1080 | PMID:11601906 PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0015734 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
31-37
Bio-Activity Profile
Antimicrobial Antiviral
channel catfish virus
virus inactivation assay
PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0055948 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
31-37
Bio-Activity Profile
Antimicrobial Antiviral
frog virus 3; channel catfish virus
virus inactivation assay
PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0056154 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Ranatuerin
8404
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
31-37
Bio-Activity Profile
Antiviral Anti-CCV Entry inhibition
channel catfish virus
50 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. | Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. | Virology. 2001 Sep 30;288(2):351-7. | DOI:10.1006/viro.2001.1080 | PMID:11601906 PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0143111 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Ranatuerin
8404
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
31-37
Bio-Activity Profile
Antiviral Anti-CCV Entry inhibition
frog virus 3; channel catfish virus
virus inactivation assay
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. | Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. | Virology. 2001 Sep 30;288(2):351-7. | DOI:10.1006/viro.2001.1080 | PMID:11601906 PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
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