Peptide Database

Peptide NameToxin CsTx-2b, Omega-ctenitoxin-Cs1a

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC278H442N86O90S9

DescriptionStandard

        SCIPKHEECTNDKHNCCRKGLFKLKCQCSTFDDESGQPTERCACGRPMGHQAIETGLNIF
    

Molecular Weight6717.59 Da

Isoelectric Point (pI)6.76

Net Charge (pH 7.0)-0.35

Net Charge (pH 7.4) -0.84

Charge Density (pH 7.0) -0.0058

GRAVY Index-0.75

Hydrophobic Moment 0.51

Boman Index-0.17

Instability Index59.51

Aliphatic Index 42.33

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2854.24

LogP -36.08

H-bond Donors 104.0

H-bond Acceptors 102.0

Rotatable Bonds 226.0

Heavy Atoms 463.0

Ring Count 9.0

Amide Bonds 65.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0037668 VERIFIED: NO

Provenance & Taxonomy

OrganismCupiennius salei [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Toxic Neurotoxic Insecticidal

PaperA lysine rich C-terminal tail is directly involved in the toxicity of CSTX-1, a neurotoxic peptide from the venom of the spider Cupiennius salei. PMID:10897091; DOI:10.1002/1520-6327(200007)44:3<101::AID-ARCH1>3.0.CO;2-S PMID10897091 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22613721/

RECORD: Rec_0042815 VERIFIED: YES