Peptide Database

Peptide Namegamma-Gliadin (p139p152; E140, E148 and E150) E residues in the gliadin peptides are introduced to mimic the deamidation mediated by tissue transglutaminase.

Function Ontology

Immunology ▸ Immunomodulation ▸ Celiac-immunogenic

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC73H109N21O26

DescriptionStandard

        PEQPQQSFPEQERP
    

Molecular Weight1696.77 Da

Isoelectric Point (pI)4.25

Net Charge (pH 7.0)-2.03

Net Charge (pH 7.4) -2.10

Charge Density (pH 7.0) -0.1452

GRAVY Index-2.39

Hydrophobic Moment 0.38

Boman Index-0.48

Instability Index175.56

Aliphatic Index 0.00

Aromaticity 0.0714

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 767.65

LogP -9.20

H-bond Donors 23.0

H-bond Acceptors 24.0

Rotatable Bonds 52.0

Heavy Atoms 120.0

Ring Count 5.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0022889 VERIFIED: YES

Provenance & Taxonomy

OrganismTriticum aestivum [Plant]

FamilyGliadin

Tax ID4565

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsDeamidation; Reported substitutions/positions: E140,E148; Reported substitutions/positions: E150

Bio-Activity Profile

Function

Celiac-immunogenic

TargetHuman intestinal T cells / HLA-DQ2

MethodIntestinal T-cell assay

RECORD: Rec_0172277 VERIFIED: YES